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Cell Res. 2013 Oct;23(10):1201-14. doi: 10.1038/cr.2013.120. Epub 2013 Sep 3.

A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity.

Author information

1
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China.

Abstract

The Hippo (Hpo) pathway controls tissue growth and organ size by regulating the activity of transcriptional co-activator Yorkie (Yki), which associates with transcription factor Scalloped (Sd) in the nucleus to promote downstream target gene expression. Here we identify a novel protein Sd-Binding-Protein (SdBP)/Tgi, which directly competes with Yki for binding to Sd through its TDU domains and inhibits the Sd-Yki transcriptional activity. We also find that SdBP retains Yki in the nucleus through the association with Yki WW domains via its PPXY motifs. Collectively, we identify SdBP as a novel component of the Hpo pathway, negatively regulating the transcriptional activity of Sd-Yki to restrict tissue growth.

PMID:
23999857
PMCID:
PMC3790236
DOI:
10.1038/cr.2013.120
[Indexed for MEDLINE]
Free PMC Article

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