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J Clin Invest. 2013 Sep;123(9):3652-8. doi: 10.1172/JCI67228. Epub 2013 Sep 3.

Oncometabolites: linking altered metabolism with cancer.

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1
Cancer Biology and Metabolism Group, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Abstract

The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we review the potential roles of such "oncometabolites" in tumor evolution and as clinical biomarkers for the detection of cancers characterized by metabolic dysregulation.

PMID:
23999438
PMCID:
PMC3754247
DOI:
10.1172/JCI67228
[Indexed for MEDLINE]
Free PMC Article
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