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Immunotherapy. 2013 Sep;5(9):989-1004. doi: 10.2217/imt.13.101.

Histone methyltransferase and histone methylation in inflammatory T-cell responses.

Author information

1
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-5942, USA.

Abstract

During immune responses, T cells require tightly controlled expression of transcriptional programs to regulate the balance between beneficial and harmful immunity. These transcriptional programs are critical for the lineage specification of effector T cells, the production of effector cytokines and molecules, and the development and maintenance of memory T cells. An emerging theme is that post-translational modification of histones by methylation plays an important role in orchestrating the expression of transcriptional programs in T cells. In this article, we provide a broad overview of histone methylation signatures for effector molecules and transcription factors in T cells, and the functional importance of histone methyltransferases in regulating T-cell immune responses.

PMID:
23998733
PMCID:
PMC3879725
DOI:
10.2217/imt.13.101
[Indexed for MEDLINE]
Free PMC Article

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