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Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Aug;21(4):843-6. doi: 10.7534/j.issn.1009-2137.2013.04.006.

[MicroRNA-193b expression in newly diagnosed leukemia patients and its significance].

[Article in Chinese]

Author information

  • 1Department of Transfusion, Fujian Medical University Union Hospital; Fujian Institute of Hematology, Fuzhou 350001, Fujian Province, China.

Abstract

This study was aimed to quantitatively detect the levels of microRNA-193b (miR-193b) in leukemia patients and explore its significance. Real time fluorescent quantitative PCR was used to detect the relative expression level of miR-193b. The expression changes of miR-193b in various types of leukemia were analyzed. Then the relationship among miR-193b expression, parts of laboratory index and the response to chemotherapy was analyzed as well. The results showed that miR-193b expression level in acute promyelocytic leukemia (APL) and chronic myeloid leukemia (CML) patients was not lower than that in normal group (P > 0.05). Except for APL, miR-193b expression level in acute myeloid leukemia (AML) patients was lower than that in normal group (P < 0.05). In AML (except for APL) patients, there was no correlation between white blood cell count (P > 0.05), the expression of CD34 (P > 0.05) and miR-193b expression level, but there was negative correlation between chemotherapy response and miR-193b expression level (P < 0.05). It is concluded that miR-193b expression level may be correlated with susceptibility of cells to chemotherapy in AML (except for APL) patients. miR-193b maybe become a new target in AML (except for APL) therapy.

PMID:
23998571
[PubMed - indexed for MEDLINE]
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