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Physiology (Bethesda). 2013 Sep;28(5):318-29. doi: 10.1152/physiol.00007.2013.

Regulation of luminal acidification by the V-ATPase.

Author information

1
Program in Membrane Biology, Center for Systems Biology, Nephrology Division, Massachusetts General Hospital, Boston, MA, USA.

Abstract

Specialized cells in the body express high levels of V-ATPase in their plasma membrane and respond to hormonal and nonhormonal cues to regulate extracellular acidification. Mutations in or loss of some V-ATPase subunits cause several disorders, including renal distal tubular acidosis and male infertility. This review focuses on the regulation of V-ATPase-dependent luminal acidification in renal intercalated cells and epididymal clear cells, which are key players in these physiological processes.

PMID:
23997191
PMCID:
PMC3768094
DOI:
10.1152/physiol.00007.2013
[Indexed for MEDLINE]
Free PMC Article

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