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Appl Environ Microbiol. 2013 Nov;79(22):7110-3. doi: 10.1128/AEM.01978-13. Epub 2013 Aug 30.

Cloning and heterologous expression of the thioviridamide biosynthesis gene cluster from Streptomyces olivoviridis.

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1
Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan.

Abstract

Thioviridamide is a unique peptide antibiotic containing five thioamide bonds from Streptomyces olivoviridis. Draft genome sequencing revealed a gene (the tvaA gene) encoding the thioviridamide precursor peptide. The thioviridamide biosynthesis gene cluster was identified by heterologous production of thioviridamide in Streptomyces lividans.

PMID:
23995943
PMCID:
PMC3811549
DOI:
10.1128/AEM.01978-13
[Indexed for MEDLINE]
Free PMC Article
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