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Nat Med. 2013 Oct;19(10):1338-44. doi: 10.1038/nm.3324. Epub 2013 Sep 1.

Tracking adipogenesis during white adipose tissue development, expansion and regeneration.

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1
Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Abstract

White adipose tissue displays high plasticity. We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We monitored adipogenesis during development, high-fat diet (HFD) feeding and cold exposure. During cold-induced 'browning' of subcutaneous fat, most 'beige' adipocytes stem from de novo-differentiated adipocytes. During HFD feeding, epididymal fat initiates adipogenesis after 4 weeks, whereas subcutaneous fat undergoes hypertrophy for a period of up to 12 weeks. Gonadal fat develops postnatally, whereas subcutaneous fat develops between embryonic days 14 and 18. Our results highlight the extensive differences in adipogenic potential in various fat depots.

PMID:
23995282
PMCID:
PMC4075943
DOI:
10.1038/nm.3324
[Indexed for MEDLINE]
Free PMC Article
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