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Nat Neurosci. 2013 Oct;16(10):1370-2. doi: 10.1038/nn.3503. Epub 2013 Sep 1.

Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain.

Author information

1] Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University, Munich, Germany. [2] Institute for Stem Cell Research, HelmholtzZentrum, Neuherberg, Germany. [3] Department of Pharmacological Sciences, University of Milan, Milan, Italy.


To examine the role of gray and white matter niches for oligodendrocyte differentiation, we used homo- and heterotopic transplantations into the adult mouse cerebral cortex. White matter-derived cells differentiated into mature oligodendrocytes in both niches with equal efficiency, whereas gray matter-derived cells did not. Thus, white matter promotes oligodendrocyte differentiation, and cells from this niche differentiate more easily, even in the less supportive gray matter environment.

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