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Antiviral Res. 2013 Oct;100(1):246-54. doi: 10.1016/j.antiviral.2013.08.014. Epub 2013 Aug 29.

Receptor recognition and cross-species infections of SARS coronavirus.

Author information

1
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address: lifang@umn.edu.

Abstract

Receptor recognition is a major determinant of the host range, cross-species infections, and pathogenesis of the severe acute respiratory syndrome coronavirus (SARS-CoV). A defined receptor-binding domain (RBD) in the SARS-CoV spike protein specifically recognizes its host receptor, angiotensin-converting enzyme 2 (ACE2). This article reviews the latest knowledge about how RBDs from different SARS-CoV strains interact with ACE2 from several animal species. Detailed research on these RBD/ACE2 interactions has established important principles on host receptor adaptations, cross-species infections, and future evolution of SARS-CoV. These principles may apply to other emerging animal viruses, including the recently emerged Middle East respiratory syndrome coronavirus (MERS-CoV). This paper forms part of a series of invited articles in Antiviral Research on "From SARS to MERS: 10years of research on highly pathogenic human coronaviruses".

KEYWORDS:

Coronavirus; Middle East respiratory syndrome; Severe acute respiratory syndrome; Spike protein; Virus evolution

PMID:
23994189
PMCID:
PMC3840050
DOI:
10.1016/j.antiviral.2013.08.014
[Indexed for MEDLINE]
Free PMC Article

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