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Fertil Steril. 2013 Dec;100(6):1704-8. doi: 10.1016/j.fertnstert.2013.07.1997. Epub 2013 Aug 29.

Short-term effects of salpingectomy during laparoscopic hysterectomy on ovarian reserve: a pilot randomized controlled trial.

Author information

1
Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina. Electronic address: austin_findley@med.unc.edu.

Abstract

OBJECTIVE:

To examine the short-term effects of salpingectomy during laparoscopic hysterectomy on ovarian reserve when ovarian preservation is planned in view of determining the feasibility of conducting the study on a larger scale.

DESIGN:

Pilot randomized controlled trial.

SETTING:

Tertiary care, academic medical center.

PATIENT(S):

Thirty premenopausal women aged 18 to 45 years undergoing laparoscopic hysterectomy with ovarian preservation for benign indications from April 2012 to September 2012.

INTERVENTION(S):

Bilateral salpingectomy (n = 15) versus no salpingectomy (n = 15) at the time of laparoscopic hysterectomy with ovarian preservation.

MAIN OUTCOME MEASURE(S):

Antimüllerian hormone (AMH) measured preoperatively, at 4 to 6 weeks postoperatively, and at 3 months postoperatively, with operative time and estimated blood loss abstracted from the medical records.

RESULT(S):

The mean AMH levels were not statistically significantly different at baseline (2.26 vs. 2.25 ng/ml), 4 to 6 weeks postoperatively (1.03 vs. 1.25 ng/ml), or 3 months postoperatively (1.86 vs. 1.82 ng/ml) among women with salpingectomy versus no salpingectomy, respectively. There was also no statistically significant temporal change in the mean AMH level from baseline to 3 months postoperatively (-0.07 vs. -0.08 ng/ml) between the two groups. No difference in operative time (116 vs. 115 minutes) or estimated blood loss (70 vs. 91 mL) was observed.

CONCLUSION(S):

Salpingectomy at the time of laparoscopic hysterectomy with ovarian preservation is a safe procedure that does not appear to have any short-term deleterious effects on ovarian reserve, as measured by AMH level. Conducting a trial of this nature that is adequately powered with long-term follow-up evaluation would be feasible and is required to definitively confirm these results.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01578759.

KEYWORDS:

Antimüllerian hormone; hysterectomy; ovarian reserve; salpingectomy

PMID:
23993887
PMCID:
PMC3844119
DOI:
10.1016/j.fertnstert.2013.07.1997
[Indexed for MEDLINE]
Free PMC Article

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