Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Cardiol. 2013 Oct 15;168(6):5135-42. doi: 10.1016/j.ijcard.2013.08.022. Epub 2013 Aug 15.

Impact of aldosterone antagonists on the substrate for atrial fibrillation: aldosterone promotes oxidative stress and atrial structural/electrical remodeling.

Author information

1
Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Jordan. Electronic address: famayyas@just.edu.jo.

Abstract

Atrial fibrillation (AF), the most common cardiac arrhythmia, is an electrocardiographic description of a condition with multiple and complex underlying mechanisms. Oxidative stress is an important driver of structural remodeling that creates a substrate for AF. Oxidant radicals may promote increase of atrial oxidative damage, electrical and structural remodeling, and atrial inflammation. AF and other cardiovascular morbidities activate angiotensin (Ang-II)-dependent and independent cascades. A key component of the renin-angiotensin-aldosterone system (RAAS) is the mineralocorticoid aldosterone. Recent studies provide evidence of myocardial aldosterone synthesis. Aldosterone promotes cardiac oxidative stress, inflammation and structural/electrical remodeling via multiple mechanisms. In HF patients, aldosterone production is enhanced. In patients and in experimental HF and AF models, aldosterone receptor antagonists have favorable influences on cardiac remodeling and oxidative stress. Therapeutic approaches that seek to reduce AF burden by modulating the aldosterone system are likely beneficial but underutilized.

KEYWORDS:

Aldosterone; Aldosterone antagonist; Atrial fibrillation; Oxidative stress

PMID:
23993726
PMCID:
PMC4062912
DOI:
10.1016/j.ijcard.2013.08.022
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center