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Arch Gerontol Geriatr. 2014 Jan-Feb;58(1):153-9. doi: 10.1016/j.archger.2013.07.007. Epub 2013 Aug 8.

Lutein extends the lifespan of Drosophila melanogaster.

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Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science & Technology, Tianjin 300457, China. Electronic address:


Lutein is one of the major carotenoids in most fruits and vegetables. The effect of lutein on the lifespan of Drosophila melanogaster was investigated. Results revealed that 0.1mg lutein/ml diet could prolong their mean lifespan from 49.0 to 54.6 days. This was consistent with a significant reduction in malonyldialdehyde (MDA) level and increase in antioxidant enzyme activities of the flies fed with lutein-treated diet compared with those fed with basal diet. Paraquat (PQ) and H2O2 treatment tests demonstrated that lutein could prolong the survival time of the flies. Real-time polymerase chain reaction (RT-PCR) analysis indicated the gene expression of superoxide dismutase (SOD; SOD1 and SOD2), and catalase (CAT) in the lutein-treated group was up-regulated relative to that of the control group. It was concluded that the lifespan-prolonging activity of lutein was partially by up-regulation of endogenous antioxidant enzymes.


AMD; CAT; Catalase; Drosophila melanogaster; Lifespan; Lutein; MDA; Malonyldialdehyde; SOD1; SOD2; Superoxide dismutase; age-related macular degeneration; catalase; copper–zinc SOD; malonyldialdehyde; manganese SOD

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