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Cell. 2013 Aug 29;154(5):962-970. doi: 10.1016/j.cell.2013.08.014.

Cyclic dinucleotides and the innate immune response.

Author information

1
Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
2
Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: john_mekalanos@hms.harvard.edu.

Abstract

Cyclic dinucleotides (CDNs) have been previously recognized as important secondary signaling molecules in bacteria and, more recently, in mammalian cells. In the former case, they represent secondary messengers affecting numerous responses of the prokaryotic cell, whereas in the latter, they act as agonists of the innate immune response. Remarkable new discoveries have linked these two patterns of utilization of CDNs as secondary messengers and have revealed unexpected influences they likely had on shaping human genetic variation. This Review summarizes these recent insights and provides a perspective on future unanswered questions in this exciting field.

PMID:
23993090
PMCID:
PMC3931520
DOI:
10.1016/j.cell.2013.08.014
[Indexed for MEDLINE]
Free PMC Article

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