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Adipocyte. 2013 Jul 1;2(3):128-34. doi: 10.4161/adip.24075. Epub 2013 Aug 1.

Sex differences in adipose tissue: It is not only a question of quantity and distribution.

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Department of Pediatric Endocrinology; Hospital Infantil Universitario Niño Jesús; Instituto de Investigación La Princesa; Madrid, Spain ; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn); Instituto de Salud Carlos III; Madrid, Spain.


Obesity and its associated secondary complications are active areas of investigation in search of effective treatments. As a result of this intensified research numerous differences between males and females at all levels of metabolic control have come to the forefront. These differences include not only the amount and distribution of adipose tissue, but also differences in its metabolic capacity and functions between the sexes. Here, we review some of the recent advances in our understanding of these dimorphisms and emphasize the fact that these differences between males and females must be taken into consideration in hopes of obtaining successful treatments for both sexes.


leptin; metabolism; morphology; sexual dimorphism; steroids

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