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Pflugers Arch. 1990 Jun;416(4):470-2.

Co-existence of myosin heavy chain I and IIa isoforms in human skeletal muscle fibres with endurance training.

Author information

1
August Krogh Institute, University of Copenhagen, Denmark.

Abstract

The myosin heavy chain (MHC) composition of single fibres from m. vastus lateralis was analysed by one-dimensional electrophoresis and immunoblotting in three groups of young men with distinct difference in physical activity patterns. No major co-existence of MHC isoforms was found in the group with some daily physical activity. In the very sedentary group, however, 19 +/- 5% (P less than 0.05) of the fibres exhibited coexistence of MHC type IIa and IIb. Further, in the endurance trained group co-existence of MHC type I and IIa was manifested in 36 +/- 4% (P less than 0.05) of the fibres. Disuse and extreme usage of muscle both give rise to an elevation in co-expression of MHC isoforms in single muscle fibres but of markedly different combination of isoforms.

PMID:
2399119
DOI:
10.1007/bf00370757
[Indexed for MEDLINE]

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