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PLoS One. 2013 Aug 26;8(8):e72376. doi: 10.1371/journal.pone.0072376. eCollection 2013.

FoxM1 promotes glioma cells progression by up-regulating Anxa1 expression.

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1
Institute of Traumatic Brain Injury and Nervous Diseases of Chinese People's Armed Police Forces, Center for Neurology and Neurosurgery of Affiliated Hospital of Logistics College of CPAPF, Tianjin, China.

Abstract

Forkhead box M1 (FoxM1) is a member of the forkhead transcription factor family and is overexpression in malignant gliomas. However, the molecular mechanisms by which FoxM1lead to glioma carcinogenesis and progression are still not well known. In the present study, we show that Anxa1 was overexpression in gliomas and predicted the poor outcome. Furthermore, Anxa1 closely related to the FoxM1 expression and was a direct transcriptional target of FoxM1. Overexpression of FoxM1 up-regulated Anxa1 expression, whereas suppression of FoxM1 expression down-regulated Anxa1 expression in glioma cells. Finally, FoxM1 enhanced the proliferation, migration, and angiogenesis in Anxa1-dependent manner both in vitro and in vivo. Our findings provide both clinical and mechanistic evidences that FoxM1 contributes to glioma development by directly up-regulating Anxa1 expression.

PMID:
23991102
PMCID:
PMC3753245
DOI:
10.1371/journal.pone.0072376
[Indexed for MEDLINE]
Free PMC Article
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