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Microb Ecol Health Dis. 2012 Aug 24;23. doi: 10.3402/mehd.v23i0.18958. eCollection 2012.

Peptides' role in autism with emphasis on exorphins.

Author information

1
Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Abstract

PROBLEM:

The nature of the peptides found increased in urine from autism needs verification of their structure, especially those that show opioid activity.

METHODS:

The peptides were separated on reverse phase C-18 HPLC in Trifluoroacetic acid-acetonitril gradients. Peaks eluting where synthetic opioids appear, and peaks that are common to most autistic children were analyzed by mass spectrometry and fragmentation pattern on a quadropole mass-spectrometer.

RESULTS:

We could demonstrate exorphins in the urine from autistic children, and their length varied from one patient to the next.

CONCLUSION:

Exorphins are found in urine of autistic children and may account for their symptoms.

KEYWORDS:

autism; exorphins; mass-spectroscopy; peptides

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