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Clin J Am Soc Nephrol. 2014 Mar;9(3):626-32. doi: 10.2215/CJN.05810513. Epub 2013 Aug 29.

Glomerular diseases: FSGS.

Author information

1
Division of Nephrology, University Health Network, University of Toronto, Toronto, Canada.

Abstract

FSGS is a lesion, not a disease. The separation into primary FSGS (a result of immunologic-mediated injury) versus secondary FSGS (related to a variety of causes) is often difficult. Even when this particular issue is carefully evaluated, the therapeutic implications are not always apparent. Newer literature on both biomarker discovery and on the genetic basis of FSGS is reviewed in this context. In addition, the thorny implications of obesity as it relates to the FSGS lesion are discussed. An overall practical algorithmic approach to the management and treatment of the FSGS lesion that integrates these controversial overlap areas is suggested.

PMID:
23990165
PMCID:
PMC3944761
DOI:
10.2215/CJN.05810513
[Indexed for MEDLINE]
Free PMC Article

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