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Nat Rev Mol Cell Biol. 2013 Oct;14(10):673-85. doi: 10.1038/nrm3644. Epub 2013 Aug 29.

Molecular control of the NEMO family of ubiquitin-binding proteins.

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Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee, DD1 5EH, Scotland, UK.


Research over the past decade has revealed how NF-κB essential modulator (NEMO; also known as IKKγ) regulates the IKKα-IKKβ signalling axis in the innate immune system. The discovery that NEMO is a polyubiquitin-binding protein and that the IKK complex is modulated by other protein kinases that are themselves controlled by polyubiquitin chains has provided a deeper molecular understanding of the non-degradative roles of ubiquitylation. New mechanistic insights of NEMO and related polyubiquitin-binding proteins have become a paradigm for how the interplay between phosphorylation and ubiquitylation controls cell signalling networks in health and disease.

[Indexed for MEDLINE]

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