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ACS Nano. 2013 Sep 24;7(9):8167-74. doi: 10.1021/nn403465a. Epub 2013 Aug 29.

Think modular: a simple apoferritin-based platform for the multifaceted detection of pancreatic cancer.

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1
Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIS T), 5 Hwarangno 14-gil, Seongbuk-gu, Seoul 136-791, Republic of Korea.

Abstract

The generation of nanosized probes often requires time-intensive and application-specific optimization processes that involve conjugating a nanoconstruct to a targeting moiety. Herein, we genetically modify apoferritin and generate a universal interface system composed of protein G and 6Ă—His-tag. The resulting construct, conferred with modularity and high targeting efficiency, is applied toward two distinct applications in the detection of a pancreatic cancer biomarker and used to demonstrate its potential in the facile exchange of nanoprobe components.

PMID:
23988226
DOI:
10.1021/nn403465a
[Indexed for MEDLINE]
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