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J Pediatr. 2013 Nov;163(5):1507-10. doi: 10.1016/j.jpeds.2013.06.045. Epub 2013 Aug 26.

Cortical folding is altered before surgery in infants with congenital heart disease.

Author information

1
Department of Pediatrics, St. Louis Children's Hospital, Washington University in St. Louis, St. Louis, MO. Electronic address: ortinau_c@kids.wustl.edu.

Abstract

Infants with congenital heart disease have altered brain development. We characterized cortical folding, a critical part of brain development, in congenital heart disease infants and demonstrated an overall decrease in cortical surface area and cortical folding with regional alterations in the right lateral sulcus and left orbitofrontal region, cingulate region, and central sulcus. These abnormalities were present prior to surgery.

KEYWORDS:

CHD; CSA; Congenital heart disease; Cortical surface area; GI; Gyrification index; MRI; Magnetic resonance imaging

PMID:
23988135
PMCID:
PMC3905308
DOI:
10.1016/j.jpeds.2013.06.045
[Indexed for MEDLINE]
Free PMC Article

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