Format

Send to

Choose Destination
BMC Med. 2013 Aug 30;11:192. doi: 10.1186/1741-7015-11-192.

Alcohol intake, wine consumption and the development of depression: the PREDIMED study.

Collaborators (186)

Toledo E, Bes-Rastrollo M, Sánchez-Tainta A, Sanjulián B, Goñi E, Marques M, García-Arellano A, Zazpe I, Basterra-Gortari J, Martínez-Lapiscina EH, Serrano-Martínez M, Díez-Espino J, Ortuño N, Berrade N, Extremera-Urabayen V, Arroyo-Azpa C, García-Pérez L, Villanueva Tellería J, Cortés Ugalde F, Sagredo Arce T, García de la Noceda Montoy MD, Vigata López MD, Arceiz Campo MT, Urtasun Samper A, Gueto Rubio MV, Churio Beraza B, Martinez JA, Martí A, Serra M, Pérez-Heras A, Viñas C, Casas R, de Santamaría L, Romero S, Baena JM, García M, Oller M, Amat J, Duaso I, García Y, Iglesias C, Simón C, Quinzavos L, Parra L, Liroz M, Benavent J, Clos J, Pla I, Amorós M, Bonet MT, Martin MT, Sánchez MS, Altirruba J, Manzano E, Altés A, Cofán M, Valls C, Sala-Vila A, Doménech M, Bulló M, González R, Molina C, Márquez F, Babio N, Sorli M, García Roselló J, Martin F, Tort R, Isach A, Costa B, Cabré JJ, Fernández-Ballart J, Tello S, Vila J, Fitó M, Schröder H, De la Torre R, Muñoz-Aguayo D, Elosúa R, Marrugat J, Ferrer M, Carrasco P, Osma R, Guillén M, Guillem-Saiz P, Portolés O, Pascual V, Riera C, Valderrama J, Serrano A, Lázaro E, Sanmartín A, Girbés A, Santamaría V, Sánchez C, Plá Z, Sánchez E, Ortega-Azorín C, González JI, Saiz C, Salaverría I, del Hierro T, Algorta J, Francisco S, Alonso A, San Vicente J, Sanz E, Felipe I, Alonso Gómez A, Loma-Osorio A, Benítez Pont R, Bianchi Alba M, Fernández-Crehuet Navajas J, Gómez-Huelgas R, Martínez-González J, Velasco García V, de Diego Salas J, Baca Osorio A, Gil Zarzosa J, Sánchez Luque JJ, Vargas López E, Sánchez Perona J, Montero Romero E, Martín Rodríguez A, Martín Arranz V, García-Valdueza M, Moñino M, Proenza A, Prieto R, Frontera G, Ginard M, Fiol F, Jover A, García J, Leal M, Martínez E, Santos JM, Ortega-Calvo M, Román P, José García F, Iglesias P, Corchado Y, Mayoral E, Lama C, López-Sabater MC, Castellote-Bargallo AI, Medina-Remón A, Tresserra-Rimbau A, Álvarez-Pérez J, Díez Benítez E, Bautista Castaño I, Maldonado Díaz I, Sarmiendo de la Fe F, Ruano C, Hernández MJ, Macías Gutiérrez B, Henríquez P, Castro I, de la Cruz E, Galera A, Soler Y, Trías F, Sarasa I, Padres E, Corbella E, Cabezas C, Vinyoles E, Rovira MA, García L, Flores G, Verdú JM, Baby P, Ramos A, Mengual L, Roura P, Yuste MC, Guarner A, Rovira A, Santamaría MI, Mata M, de Juan C, Brau A, Mitjavila MT, Portillo MP, Sáez G, Tur J.

Author information

1
Department of Preventive Medicine and Public Health, Medical School-Clinica Universidad de Navarra, Pamplona, Spain. mamartinez@unav.es.

Abstract

BACKGROUND:

Alcoholic beverages are widely consumed. Depression, the most prevalent mental disorder worldwide, has been related to alcohol intake. We aimed to prospectively assess the association between alcohol intake and incident depression using repeated measurements of alcohol intake.

METHODS:

We followed-up 5,505 high-risk men and women (55 to 80 y) of the PREDIMED Trial for up to seven years. Participants were initially free of depression or a history of depression, and did not have any history of alcohol-related problems. A 137-item validated food frequency questionnaire administered by a dietician was repeated annually to assess alcohol intake. Participants were classified as incident cases of depression when they reported a new clinical diagnosis of depression, and/or initiated the use of antidepressant drugs. Cox regression analyses were fitted over 23,655 person-years.

RESULTS:

Moderate alcohol intake within the range of 5 to 15 g/day was significantly associated with lower risk of incident depression (hazard ratio (HR) and 95% confidence interval (95% CI) = 0.72 (0.53 to 0.98) versus abstainers). Specifically, wine consumption in the range of two to seven drinks/week was significantly associated with lower rates of depression (HR (95% CI) = 0.68 (0.47 to 0.98)).

CONCLUSIONS:

Moderate consumption of wine may reduce the incidence of depression, while heavy drinkers seem to be at higher risk.

PMID:
23988010
PMCID:
PMC3765610
DOI:
10.1186/1741-7015-11-192
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center