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Carbohydr Polym. 2013 Oct 15;98(1):8-16. doi: 10.1016/j.carbpol.2013.04.057. Epub 2013 Apr 28.

Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L.

Author information

1
State Key Laboratory of Natural Medicines, PR China.

Abstract

Diabetes mellitus is a group of complicated metabolic disorders characterized by high blood glucose level and inappropriate insulin secreting capacity due to decreased glucose metabolism and pancreatic β cell mass or dysfunction of β cells. Thus, improving glucose metabolism and preserving β cell mass and function might be useful for the treatment of diabetes. In this study, a novel acidic polysaccharide LBP-s-1 extracted from Lycium barbarum L. was obtained by purification using macroporous resin and ion-exchanged column. Monosaccharide composition analysis indicated that LBP-s-1 was comprised of rhamnose, arabinose, xylose, mannose, glucose, galactose, galacturonic acid in the molar ratio of 1.00:8.34:1.25:1.26:1.91:7.05:15.28. The preliminary structure features of LBP-s-1 were investigated by FT-IR, (1)H NMR and (13)C NMR. In vitro and in vivo hypoglycemic experiments showed that LBP-s-1 had significant hypoglycemic effects and insulin-sensitizing activity through increasing glucose metabolism and insulin secretion and promoting pancreatic β cell proliferation. Preliminary mechanisms were also elucidated.

KEYWORDS:

Glucose utilization; Hypoglycemic effect; Insulin resistance; Lycium barbarum polysaccharide

PMID:
23987311
DOI:
10.1016/j.carbpol.2013.04.057
[Indexed for MEDLINE]

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