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Metabolism. 2013 Dec;62(12):1788-94. doi: 10.1016/j.metabol.2013.07.008. Epub 2013 Aug 27.

Circulating 25-hydroxyvitamin D is associated with insulin resistance cross-sectionally but not longitudinally in older adults: The Cardiovascular Health Study.

Author information

1
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA. Electronic address: jdanzige@bidmc.harvard.edu.

Abstract

BACKGROUND:

Despite extensive study, the role of vitamin D in insulin resistance and secretion remains unclear.

OBJECTIVE:

To examine the cross-sectional and longitudinal relationships between 25-hydroxyvitamin D (25(OH)D) concentrations and indices of insulin resistance and secretion in older adults.

METHODS AND RESULTS:

Among 2134 participants of the Cardiovascular Health Study who were free from cardiovascular disease, we measured serum 25(OH)D concentrations in samples collected in 1992-1993. We examined insulin resistance and secretion using Homeostasis Model Assessment (HOMA) estimates cross-sectionally and among 1469 participants who had repeated HOMA measures four years later (1996-1997). In cross-sectional analysis, each 10 ng/mL increment in 25(OH)D concentration was associated with a 0.09 lower adjusted HOMA-IR [95% CI (-0.17, -0.02), p=0.01]. However, baseline 25(OH)D concentrations were not associated with change in HOMA-IR over 4 years of follow up (p=0.48). 25(OH)D concentrations were not associated with insulin secretion, as determined by HOMA-β, in either cross-sectional or longitudinal analysis.

CONCLUSIONS:

Circulating 25(OH)D concentrations are associated with lower insulin resistance in cross-sectional but not longitudinal analyses. Whether this reflects residual confounding in cross-sectional analyses or the short-term nature of the relationship between vitamin D and insulin sensitivity will require trials with repeated measures of these factors.

KEYWORDS:

25(OH)D; 25-hydroxyvitamin D; BMI; Body mass index; CES-D; CHS; Cardiovascular Health Study; Center for Epidemiological Studies Depression; HOMA; Homeostasis Model Assessment; Insulin resistance; Vitamin D

PMID:
23987236
PMCID:
PMC4159161
DOI:
10.1016/j.metabol.2013.07.008
[Indexed for MEDLINE]
Free PMC Article

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