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Gan To Kagaku Ryoho. 2013 Aug;40(8):1093-7.

[A case of liver metastasis from gastric cancer responding completely to S-1/docetaxel chemotherapy].

[Article in Japanese]

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  • 1Dept. of Surgery and Sciences, Graduate School of Medical Sciences Kyushu University.

Abstract

A 68-year-old man was introduced to our hospital with right lower abdominal pain. Endoscopic examination and abdominal CT revealed gastric cancer with liver metastasis. We started chemotherapy using S-1(120 mg/body/day), orally administered for 2 weeks followed by a 2-week rest period, and docetaxel(35 mg/m(2)), administered intravenously on day 1 and 15 as 1 course. After 4 courses of chemotherapy, the liver tumor reduced markedly and no new cancerous region was found by examination; therefore total gastrectomy and partial hepatectomy were performed. Histological examination showed an undifferentiated adenocarcinoma remaining as Grade 1b in the resected stomach. A resected specimen of the liver showed necrotic tissue without any cancer cells. This case suggests that S-1/docetaxel chemotherapy may reduce the stage of unresectable liver metastasis from gastric cancer and make a curative operation possible.

PMID:
23986059
[PubMed - indexed for MEDLINE]
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