Format

Send to

Choose Destination
Sci Rep. 2013;3:2535. doi: 10.1038/srep02535.

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus.

Author information

1
1] Biotech Research and Innovation Centre and Centre for Epigenetics, University of Copenhagen, Denmark [2].

Abstract

microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we report that microRNA-9 (miR-9) regulates the expression of the Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT-1), one of the most abundant and conserved long non-coding RNAs. Intriguingly, we find that miR-9 targets AGO2-mediated regulation of MALAT1 in the nucleus. Our findings reveal a novel direct regulatory link between two important classes of non-coding RNAs, miRs and lncRNAs, and advance our understanding of microRNA functions.

PMID:
23985560
PMCID:
PMC3756333
DOI:
10.1038/srep02535
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center