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J Microbiol Biotechnol. 2013 Nov 28;23(11):1636-40.

Effect of orally administered Lactobacillus brevis HY7401 in a food allergy mouse model.

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Laboratory of Immunology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.


We had found that orally administered Lactobacillus species were effective immune modulators in ovalbumin (OVA)-sensitized mice. To validate these findings, we investigated the effects of orally administered Lactobacillus brevis HY7401 in OVA-T cell receptor transgenic mice. This strain showed a tendency to induce Th1 cytokines and inhibit Th2 cytokines. All assayed isotypes of OVA-specific antibody were effectively reduced. Systemic anaphylaxis was also relatively reduced with the probiotic administration. These results reveal that L. brevis HY7401 might be useful to promote anti-allergic processes through oral administration.

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