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J Clin Exp Neuropsychol. 2013;35(8):882-95. doi: 10.1080/13803395.2013.828021. Epub 2013 Aug 28.

Direct and mediated effects of cognitive function with multidimensional outcome measures in schizophrenia: the role of functional capacity.

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a Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California , San Diego , CA , USA.


Although cognitive ability is a known predictor of real-world functioning in schizophrenia, there has been an expanded interest in understanding the mechanisms by which it explains real-world functioning in this population. We examined the extent to which functional capacity (i.e., skills necessary to live independently) mediated the relationship between cognitive ability and both observer and self-reported real-world functioning in 138 outpatients with schizophrenia. Functional capacity significantly mediated the relations between cognitive ability and observer-rated real-world functioning, but not self-reported real-world functioning, with small to medium effect sizes observed for all outcomes. The role of cognitive ability in observer versus self-reported real-world functioning may be explained by different mechanisms.

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