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Clin Dev Immunol. 2013;2013:285246. doi: 10.1155/2013/285246. Epub 2013 Jul 24.

The controversial role of microglia in malignant gliomas.

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1
Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-1402, USA.

Abstract

Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs can retain intrinsic anti-tumor properties. Here, we review and discuss this duality and the potential therapeutic strategies that may inhibit their glioma-supportive and propagating functions.

PMID:
23983766
PMCID:
PMC3741958
DOI:
10.1155/2013/285246
[Indexed for MEDLINE]
Free PMC Article
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