Flavonoids from Sudanese Albizia zygia (Leguminosae, subfamily Mimosoideae), a plant with antimalarial potency

Afr J Tradit Complement Altern Med. 2011 Oct 2;9(1):56-8. doi: 10.4314/ajtcam.v9i1.8. eCollection 2012.

Abstract

Three flavonoids were isolated for the first time from the Sudanese medicinal plants Albizia zygia. Compounds 1-3 were identified by interpretation of ESI mass data, (1)H, (13)C and 2D NMR as well as by comparison with published data as 4',7-dihydroxyflavanone (1) 3',4',7-trihydroxyflavone (2), 3-O-methylfisetin (3',4',7-trihydroxy-3-methoxyflavone, 3). All flavonoids were tested against Plasmodium falciparum, and only compound 2 showed high antimalarial activity (IC50 0.078 µg/ml).

Keywords: Albizia zygia; Mimosoideae; antimalarial activity; flavonoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albizzia / chemistry*
  • Antimalarials / isolation & purification
  • Antimalarials / pharmacology*
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology*
  • Inhibitory Concentration 50
  • Molecular Structure
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plants, Medicinal
  • Plasmodium falciparum / drug effects*
  • Sudan

Substances

  • 3',4',7-trihydroxyflavone
  • Antimalarials
  • Flavonoids
  • Plant Extracts