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J Acquir Immune Defic Syndr. 2014 Jan 1;65(1):27-32. doi: 10.1097/QAI.0b013e3182a990e2.

ACSM4 polymorphisms are associated with rapid AIDS progression in HIV-infected patients.

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1
*Unidad de Coinfección HIV/Hepatitis, Centro Nacional de Microbiología, Hospital Carlos III, Madrid, Spain; †Plataforma de Laboratorio, Hospital General Universitario "Gregorio Marañón," Madrid, Spain; ‡Fundación para la Investigación Biomédica, Hospital General Universitario "Gregorio Marañón," Madrid, Spain; §Servicio de Enfermedades Infecciosas, Hospital Carlos III, Madrid, Spain; ‖Servicio Microbiología, Hospital General Universitario Gregorio Marañon, Madrid, Spain; ¶Servicio de Enfermedades Infecciosas, Hospital General Universitario Reina Sofia, Madrid, Spain; #Servicio de Enfermedades Infecciosas, Hospital Virgen del Rocío, Seville, Spain; **Laboratorio InmunoBiología Molecular, Hospital General Universitario Gregorio Marañón, Madrid, Spain; ††Instituto de Investigación Sanitaria del Gregorio Marañón, Madrid, Spain; and ‡‡Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.

Abstract

: Our aim was to explore the association among ACSM4 and PECI polymorphisms and AIDS progression in 454 HIV-infected patients never treated with antiretroviral drugs (146 long-term nonprogressors, 228 moderate progressors, and 80 rapid progressors). For ACSM4 polymorphisms, rs7137120 AA/AG and rs7961991 CC/CT genotypes had higher odds of having a rapid AIDS progression [odds ratio (OR) = 3.21; 95% of confidence interval (95% CI) = 1.26 to 8.16; P = 0.014 and OR = 3.60; 95% CI = 1.38 to 9.36; P = 0.009, respectively]. Additionally, the ACSM4 haplotype integrated for both rs7961991 A and rs7137120 C alleles had higher odds of having a rapid AIDS progression (OR = 2.85; 95% CI = 1.28 to 6.25; P = 0.010). For PECI polymorphisms, no significant associations were found. In conclusion, ACSM4 polymorphisms might play a significant role in AIDS progression.

PMID:
23982661
DOI:
10.1097/QAI.0b013e3182a990e2
[Indexed for MEDLINE]
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