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Chem Commun (Camb). 2013 Oct 11;49(79):9033-5. doi: 10.1039/c3cc45216f.

Enzyme-responsive supramolecular nanovalves crafted by mesoporous silica nanoparticles and choline-sulfonatocalix[4]arene [2]pseudorotaxanes for controlled cargo release.

Author information

1
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, P. R. China. ywyang@jlu.edu.cn yywfrank@gmail.com.

Abstract

Mesoporous silica nanoparticles (MSNs) have been surface-functionalized with choline moieties encircled by sulfonatocalix[4]arenes. Two enzyme cleavable sites are incorporated in the stalks for specific enzymes to regulate the release of loaded cargos from MSNs. These gated materials show a clear enzymatic response and proven orthogonality.

PMID:
23982479
DOI:
10.1039/c3cc45216f
[Indexed for MEDLINE]
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