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Arq Neuropsiquiatr. 2013 Aug;71(8):537-9. doi: 10.1590/0004-282X20130074.

Autonomic evaluation of hepatitis C virus infected patients.

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Department of Internal Medicine and Neuro, UPC, Rio de Janeiro RJ, Brazil.


There are few studies reporting the association between hepatitis C virus (HCV) infection and disautonomia. We have evaluated the autonomic cardiovascular function in 12 patients with sensory small-fiber polyneuropathy infected by HCV. The mean age was 49 ± 13 years old. The mean infection time was 9.6 years in six (50%) patients. Thermal and pinprick hypoesthesia was observed in distal legs in all patients. Autonomic symptoms were referred by eight (66.7%) patients. Among patients with abnormal autonomic cardiovascular test, five (41.7%) showed abnormal results in two or more tests. Valsalva maneuver was abnormal in seven (58.3%) patients. We can consider that there is an association of both parasympathetic and sympathetic efferent cardiovascular dysfunction in this group of patients.

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