Format

Send to

Choose Destination
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Aug;38(8):809-17. doi: 10.3969/j.issn.1672-7347.2013.08.009.

[miR-126 inhibits colon cancer proliferation and invasion through targeting IRS1, SLC7A5 and TOM1 gene].

[Article in Chinese]

Author information

1
Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013,China.

Abstract

OBJECTIVE:

To explore the expression pattern and function of miR-126 in human colon cancer and the underlying mechanisms.

METHODS:

The expression pattern of miR-126 in high-density human colon cancer tissue microarray was analyzed by in situ hybridization. Further more, the biological function of miR-126 in colon cancer in vitro was investigated by establishing a stable miR-126 over-expression cell lines.

RESULT:

The expression of miR-126 was lower in the tumor tissue, especially in metastasis tissue. The down-regulation of miR-126 was more obvious in the patients who displayed bad prognosis (P=0.025). Over-expression of miR-126 in colon cancer cell was able to inhibit cell proliferation, promote cell apoptosis and reduce the invasive ability. MiR-126 significantly enhanced the sensitivity of the colon cancer cell to chemotherapeutic drug. It has been shown that IRS1, SLC75A and TOM1 were the potential target genes of miR-126 in colon cancer.

CONCLUSION:

MiR-126 was able to inhibit the development of colon cancer and its level was closely related with the prognosis of patients with colon cancer. The potential target genes for miR-126 might include IRS1, SLC7A5 and TOM1. Therefore, miR-126 might be a therapeutic target for colon cancer diagnosis and treatment.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for CENTRAL SOUTH UNIVERSITY
Loading ...
Support Center