Format

Send to

Choose Destination
Cancer Lett. 2014 Apr 10;345(2):203-9. doi: 10.1016/j.canlet.2013.08.015. Epub 2013 Aug 24.

Chronic pancreatitis: a path to pancreatic cancer.

Author information

1
Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, Australia.
2
Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, Australia; Macarthur Cancer Therapy Centre, Campbelltown Hospital, Campbelltown, Australia.
3
Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, Australia; St. Vincent's Clinical School, University of New South Wales, Sydney, Australia; Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: i.rooman@garvan.org.au.

Abstract

Chronic pancreatitis predisposes to pancreatic cancer development and both diseases share a common etiology. A central role has been proposed for the digestive enzyme-secreting acinar cell that can undergo ductal metaplasia in the inflammatory environment of pancreatitis. This metaplastic change is now a recognised precursor of pancreatic cancer. Inflammatory molecules also foster tumour growth through autocrine and paracrine effects in the epithelium and the stroma. These insights have raised new opportunities such as the manipulation of inflammation as a preventive and/or therapeutic strategy for pancreatic cancer. Finally, we address the need for an in-depth study of the pancreatic acinar cells.

KEYWORDS:

Acinar to ductal metaplasia; Dedifferentiation; Inflammation; Oxidative stress; Pancreatic cancer; Pancreatitis

PMID:
23981573
DOI:
10.1016/j.canlet.2013.08.015
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center