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Adv Drug Deliv Rev. 2014 May;71:2-14. doi: 10.1016/j.addr.2013.08.008. Epub 2013 Aug 24.

Drug delivery to the central nervous system by polymeric nanoparticles: what do we know?

Author information

1
Institut für Pharmazeutische Technologie, Goethe-Universtät, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany. Electronic address: kreuter@em.uni-frankfurt.de.

Abstract

Nanoparticles enable the delivery of a great variety of drugs including anticancer drugs, analgesics, anti-Alzheimer's drugs, cardiovascular drugs, protease inhibitors, and several macromolecules into the brain after intravenous injection of animals. The mechanism of the nanoparticle-mediated drug transport across the BBB appears to be receptor-mediated endocytosis followed by transcytosis into the brain or by drug release within the endothelial cells. Modification of the nanoparticle surface with covalently attached targeting ligands or by coating with certain surfactants that lead to the adsorption of specific plasma proteins after injection is necessary for this receptor-mediated uptake. A very critical and important requirement for nanoparticulate brain delivery is that the employed nanoparticles are biocompatible and, moreover, rapidly biodegradable, i.e. over a time frame of a few days. In addition to enabling drug delivery to the brain, nanoparticles, as with doxorubicin, may importantly reduce the drug's toxicity and adverse effects due to an alteration of the body distribution. Because of the possibility to treat severe CNS diseases such as brain tumours and to even transport proteins and other macromolecules across the blood-brain barrier, this technology holds great promise for a non-invasive therapy of these diseases.

KEYWORDS:

Brain targeting; Brain tumours; Drug delivery; Glioblastomas; Nanoparticles

PMID:
23981489
DOI:
10.1016/j.addr.2013.08.008
[Indexed for MEDLINE]
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