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Clin Exp Rheumatol. 2013 Sep-Oct;31(5):788-94. Epub 2013 Aug 2.

New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children.

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Department of Pediatrics, University of Chieti, Chieti, Italy.


Pericarditis has several different causes, however, in about 70% of paediatric patients, a specific aetiology cannot be detected and the pericarditis is considered idiopathic. Recurrences may occur in up to 15-30% of cases. The pathogenesis of recurrent disease is controversial. Infectious, autoimmune and autoinflammatory pathways have been proposed as mechanisms involved in recurrences. Therapeutic strategies are not standardised, non-steroidal anti-inflammatory drugs at high dosages being the mainstay of therapy with the possible addition of low dose colchicine to prevent recurrences. Biological agents are considered a possible new therapeutic frontiers in the care of idiopathic recurrent pericarditis.

[Indexed for MEDLINE]

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