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Cell Res. 2013 Nov;23(11):1247-8. doi: 10.1038/cr.2013.115. Epub 2013 Aug 27.

Mechanisms of apoptotic phosphatidylserine exposure.

Author information

1
1] INSERM, U848, F-94805 Villejuif, France [2] Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France.

Abstract

It has been a long-standing enigma which scramblase causes phosphatidylserine residues to be exposed on the surface of apoptotic cells, thereby facilitating the phagocytic recognition, engulfment and destruction of apoptotic corpses. In a recent paper in Science, Nagata and coworkers reveal that the scramblases Xkr8 and its C. elegans ortholog, CED-8, are activated by caspase cleavage in apoptotic cells.

PMID:
23979019
PMCID:
PMC3817543
DOI:
10.1038/cr.2013.115
[Indexed for MEDLINE]
Free PMC Article

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