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Cell Res. 2013 Dec;23(12):1337-8. doi: 10.1038/cr.2013.119. Epub 2013 Aug 27.

A chemical logic for reprogramming to pluripotency.

Author information

1
1] Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA [2] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA [3] Broad Institute, Boston, MA 02115, USA [4] Harvard Stem Cell Institute, Boston, MA 02115, USA.

Abstract

Pluripotency can be experimentally induced from somatic cells by nuclear transfer, fusion with embryonic stem cells, or ectopic transcription factor induction, but attempts to recapitulate this process by chemical means alone have previously failed. In a recent paper published in Science, Hou et al. pursue a rational, albeit laborious approach to identify cocktails of small molecules whose treatment restores pluripotency in adult somatic cells.

PMID:
23979017
PMCID:
PMC3847567
DOI:
10.1038/cr.2013.119
[Indexed for MEDLINE]
Free PMC Article

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