Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Commun. 2013;4:2258. doi: 10.1038/ncomms3258.

Role of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice.

Author information

1
1] Max Planck Institute for Medical Research, 69120 Heidelberg, Germany [2] Charité-Universitätsmedizin, NeuroCure Cluster of Excellence, 12101 Berlin, Germany.

Erratum in

  • Nat Commun. 2013;4:2831.

Abstract

The primary motor cortex has an important role in the precise execution of learned motor responses. During motor learning, synaptic efficacy between sensory and primary motor cortical neurons is enhanced, possibly involving long-term potentiation and N-methyl-D-aspartate (NMDA)-specific glutamate receptor function. To investigate whether NMDA receptor in the primary motor cortex can act as a coincidence detector for activity-dependent changes in synaptic strength and associative learning, here we generate mice with deletion of the Grin1 gene, encoding the essential NMDA receptor subunit 1 (GluN1), specifically in the primary motor cortex. The loss of NMDA receptor function impairs primary motor cortex long-term potentiation in vivo. Importantly, it impairs the synaptic efficacy between the primary somatosensory and primary motor cortices and significantly reduces classically conditioned eyeblink responses. Furthermore, compared with wild-type littermates, mice lacking NMDA receptors in the [corrected] primary motor cortex show slower learning in Skinner-box tasks. Thus, primary motor cortex NMDA receptors are necessary for activity-dependent synaptic strengthening and associative learning.

PMID:
23978820
PMCID:
PMC3759079
DOI:
10.1038/ncomms3258
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center