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Transfus Apher Sci. 2014 Jun;50(3):322-9. doi: 10.1016/j.transci.2013.07.031. Epub 2013 Aug 8.

Mechanistic insights into extracorporeal photochemotherapy: efficient induction of monocyte-to-dendritic cell maturation.

Author information

1
Aaron and Marguerite Lerner Professor and Chairman, Department of Dermatology, Yale University School of Medicine, USA. Electronic address: redelson@yale.edu.

Abstract

Extracorporeal photochemotherapy (ECP) is a widely used immunotherapy for cutaneous T cell lymphoma, as well as immunomodulation of graft-versus-host disease (GVHD) and transplanted organ rejection. ECP's mechanism encompasses large-scale physiologic platelet induction of dendritic cells (DCs). The normal bidirectional immunologic talents of DCs likely contribute heavily to ECP's capacity to immunize against tumor antigens, while also suppressing transplant immunopathology. Our understanding of how ECP physiologically induces monocyte-to-DC maturation can enhance the treatment's potency, potentially broaden its use to other cancers and autoimmune disorders and tailor its application to individual patients' diseases. ECP's next decade is filled with promise.

KEYWORDS:

Antigen-presenting cells; Cancer; Dendritic cells; Photopheresis; Tolerance

PMID:
23978554
PMCID:
PMC4075109
DOI:
10.1016/j.transci.2013.07.031
[Indexed for MEDLINE]
Free PMC Article

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