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Curr Opin Virol. 2013 Oct;3(5):521-30. doi: 10.1016/j.coviro.2013.07.007. Epub 2013 Aug 24.

Influenza virus hemagglutinin stalk-based antibodies and vaccines.

Author information

1
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: Florian.Krammer@mssm.edu.

Abstract

Antibodies against the conserved stalk domain of the hemagglutinin are currently being discussed as promising therapeutic tools against influenza virus infections. Because of the conservation of the stalk domain these antibodies are able to broadly neutralize a wide spectrum of influenza virus strains and subtypes. Broadly protective vaccine candidates based on the epitopes of these antibodies, for example, chimeric and headless hemagglutinin structures, are currently under development and show promising results in animals models. These candidates could be developed into universal influenza virus vaccines that protect from infection with drifted seasonal as well as novel pandemic influenza virus strains therefore obviating the need for annual vaccination, and enhancing our pandemic preparedness.

PMID:
23978327
PMCID:
PMC3804342
DOI:
10.1016/j.coviro.2013.07.007
[Indexed for MEDLINE]
Free PMC Article

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