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Alzheimers Dement. 2014 Jul;10(4):477-84.e1. doi: 10.1016/j.jalz.2013.06.003. Epub 2013 Aug 24.

A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank.

Author information

1
Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA.
2
Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
3
Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
4
Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
5
Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA. Electronic address: trojanow@mail.med.upenn.edu.

Abstract

Neurodegenerative diseases (NDs) are defined by the accumulation of abnormal protein deposits in the central nervous system (CNS), and only neuropathological examination enables a definitive diagnosis. Brain banks and their associated scientific programs have shaped the actual knowledge of NDs, identifying and characterizing the CNS deposits that define new diseases, formulating staging schemes, and establishing correlations between neuropathological changes and clinical features. However, brain banks have evolved to accommodate the banking of biofluids as well as DNA and RNA samples. Moreover, the value of biobanks is greatly enhanced if they link all the multidimensional clinical and laboratory information of each case, which is accomplished, optimally, using systematic and standardized operating procedures, and in the framework of multidisciplinary teams with the support of a flexible and user-friendly database system that facilitates the sharing of information of all the teams in the network. We describe a biobanking system that is a platform for discovery research at the Center for Neurodegenerative Disease Research at the University of Pennsylvania.

KEYWORDS:

Alzheimer's Disease; Autopsy; Cerebrospinal fluid; Dementia; Frontotemporal lobar degeneration; Genetics; Neurodegeneration; Parkinson's Disease; Plasma; Serum

PMID:
23978324
PMCID:
PMC3933464
DOI:
10.1016/j.jalz.2013.06.003
[Indexed for MEDLINE]
Free PMC Article

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