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Ann Cardiothorac Surg. 2013 Jul;2(4):435-43. doi: 10.3978/j.issn.2225-319X.2013.05.04.

Biomechanics and biocompatibility of the perfect conduit-can we build one?

Author information

1
The Baird Institute for Applied Heart and Lung Surgical Research, Sydney, Australia; ; Royal Prince Alfred Hospital, Sydney, Australia; ; University of Sydney, Sydney, Australia;

Abstract

No currently available conduit meets the criteria for an ideal coronary artery bypass graft. The perfect conduit would combine the availability and complication-free harvest of a synthetic vessel with the long-term patency performance of the internal mammary artery. However, current polymer conduits suffer from inelastic mechanical properties and especially poor surface biocompatibility, resulting in early loss of patency as a coronary graft. Approaches to manufacture an improved conduit using new polymers or polymer surfaces, acellular matrices, or cellular constructs have to date failed to achieve a commercially successful alternative. Elastin, by mimicking the native extracellular environment as well as providing elasticity, provides the 'missing link' in vascular conduit design and brings new hope for realization of the perfect conduit.

KEYWORDS:

Coronary artery bypass; biocompatible materials; biomechanics; blood vessel prosthesis

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