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Nat Neurosci. 2013 Oct;16(10):1367-9. doi: 10.1038/nn.3498. Epub 2013 Aug 25.

Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference.

Author information

1
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, California, USA.

Abstract

Contextual cues associated with previous drug exposure can trigger drug craving and seeking, and form a substantial obstacle in substance use recovery. Using in vivo imaging in mice, we found that cocaine administration induced a rapid increase in the formation and accumulation of new dendritic spines, and that measures of new persistent spine gain correlated with cocaine conditioned place preference. Our data suggest that new persistent spine formation in the frontal cortex may be involved in stimulant-related learning driving appetitive behavior.

PMID:
23974707
PMCID:
PMC3940437
DOI:
10.1038/nn.3498
[Indexed for MEDLINE]
Free PMC Article

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