Format

Send to

Choose Destination
See comment in PubMed Commons below
Organogenesis. 2013 Jul-Sep;9(3):121-4. doi: 10.4161/org.25586. Epub 2013 Jul 3.

Adaptive inflammatory microenvironment for cell-based regeneration in ischemic cardiovascular disease.

Author information

1
Department of Cardiology & Molecular Imaging Program; Xijing Hospital; Fourth Military Medical University; Xi'an, PR China.

Abstract

Cell-based therapy has emerged to be a promising strategy for alleviating the heavy burden of ischemic cardiovascular disease for nearly two decades, despite a variety of pending questions about its availability and efficacy. One question is whether and how the cells behave for regeneration in vivo, which could be limited or potentiated by the inflammatory microenvironment following myocardial infarction or critical limb ischemia. To this end, we hypothesize that the "adaptive inflammatory microenvironment" is pertinent to the cell-based regeneration, and make a brief comment on it based upon recent evidence.

KEYWORDS:

cell transplantation; endogenous cardiac regeneration; inflammatory microenvironment; ischemic cardiovascular disease; tissue regeneration

PMID:
23974172
PMCID:
PMC3896581
DOI:
10.4161/org.25586
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Support Center