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FEBS Lett. 2013 Oct 1;587(19):3175-81. doi: 10.1016/j.febslet.2013.07.048. Epub 2013 Aug 20.

MALAT-1 interacts with hnRNP C in cell cycle regulation.

Author information

1
Institute of Molecular Medicine and State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100871, China.

Abstract

As a conserved non-coding RNA gene, transcripts of MALAT-1 localize predominately in the nucleus. However in G2/M cell cycle phase, MALAT-1 transcripts were surprisingly found to translocate from the nucleus into the cytoplasm. Investigation also found that in this process MALAT-1 interacts with an abundant nuclear factor, hnRNP C protein. Using a loss-of-function assay, we found that down-regulation of MALAT-1 expression compromised the cytoplasmic translocation of hnRNP C in the G2/M phase and resulted in G2/M arrest. In addition to characterize the physiological interaction between MALAT-1 and hnRNP C, our study also highlights the role of MALAT-1 in cell cycle regulation.

KEYWORDS:

Cell cycle; Long non-coding RNA; MALAT-1; hnRNP C

PMID:
23973260
DOI:
10.1016/j.febslet.2013.07.048
[Indexed for MEDLINE]
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