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Immunity. 2013 Aug 22;39(2):201-3. doi: 10.1016/j.immuni.2013.08.017.

A degrading view of regulatory T cells.

Author information

1
National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.

Abstract

Studies by van Loosdregt et al. and Chen et al. in this issue of Immunity provide evidence for previously unrecognized players that regulate FOXP3 degradation. These are interesting developments that point to unappreciated mechanisms by which inflammatory signals can impact expression of FOXP3 and possibly the stability of Treg cell phenotypes.

PMID:
23973216
DOI:
10.1016/j.immuni.2013.08.017
[Indexed for MEDLINE]
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