Format

Send to

Choose Destination
See comment in PubMed Commons below
Bioorg Med Chem Lett. 2013 Oct 1;23(19):5279-82. doi: 10.1016/j.bmcl.2013.08.007. Epub 2013 Aug 11.

Design, synthesis and biological evaluation of peptide derivatives of L-dopa as anti-parkinsonian agents.

Author information

1
School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang 310035, PR China. taozhou@zjgsu.edu.cn

Abstract

A series of dipeptide derivatives of L-dopa were synthesized and investigated for their pharmacological activity using the unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rat as an experimental model of Parkinson's disease. Among them, (S)-isopropyl 2-(2-amino-2-methylpropanamido)-3-(3,4-dihydroxyphenyl)propanoate (4 g) was found to be the most active compound, with 106% AUC activity and 149% peak activity of L-dopa after oral administration.

KEYWORDS:

6-Hydroxydopamine (6-OHDA) lesioned rat; Parkinson’s disease; Prodrug; l-Dopa

PMID:
23973169
DOI:
10.1016/j.bmcl.2013.08.007
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center