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Travel Med Infect Dis. 2013 Nov-Dec;11(6):412-20. doi: 10.1016/j.tmaid.2013.05.003. Epub 2013 Aug 22.

Clinical aspects and management of cutaneous leishmaniasis in rheumatoid patients treated with TNF-α antagonists.

Author information

1
Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland; University of Basel, Petersplatz 1, 4033 Basel, Switzerland. Electronic address: andreas.neumayr@unibas.ch.

Abstract

Patients under immunosuppressive therapy with tumor necrosis factor alpha (TNF-α) antagonists are vulnerable to various opportunistic infections including leishmaniasis. We present a case series of 8 travellers developing cutaneous leishmaniasis whilst on TNF-α antagonist treatment and review the literature on aspects of cutaneous leishmaniasis developing in patients treated with TNF-α antagonists. We make interim recommendations regarding the drug therapy used to maintain remission in travellers with rheumatoid disease travelling to leishmania prone areas. Despite having a medical condition requiring continued rheumatological review the interval to diagnosis appears not to be reduced compared to that described in non-rheumatoid patients. Rheumatologists and family doctors should be aware of the need for post-travel surveillance for leishmaniasis in rheumatoid patients on TNF-alpha antagonist treatment.

KEYWORDS:

Cutaneous leishmaniasis; Immunosuppression; Rheumatology; TNF-alpha antagonists; Treatment

PMID:
23972958
DOI:
10.1016/j.tmaid.2013.05.003
[Indexed for MEDLINE]

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